Based on 2015 published peer-review study when provided as FB3, Coleus forskohli, Salacia reticulata, and Sesamum indicum supply a safe and eﬀective method preventing excess body fat. A clinical study showed that FB3 led to diminished visceral fat, body triglycerides, food cravings and caloric intake. And, an in vitro study found that the synergistic action of the Coleus forskohlii and Salacia reticulata in FB3 inhibited fat absorption by 20.7% – almost double the sum of the fat-inhibiting activity generated by each component alone. Journal of Functional Foods 18 (2015) 994–1001
But perhaps the most exciting result of this FB3 study is identiﬁcation of the ingredient’s complementary mechanism which occurs with the interaction of Coleus forskohlii and Sesamum indicum. This mechanism is intended to moderate FB3’s fat-inhibition abilities: in vitro in the low dose Sesamum indicum helps fat-inhibiting activity of the FB3 ingredients; with the higher dose Sesamum indicum gradually moderates the fat-inhibition with Coleus forskohlii, hence providing the inherent “safty mechanims” of the FB3. Journal of Functional Foods 18 (2015) 994–1001
The study also showed that Coleus forskohli, Salacia reticulata and Sesamum indicum work synergistically to prevent phenomenon of diminished response to regularly consumed ingredients for targeted action over time. This means that FB3 won’t become less eﬀective over time or as people age – which is a problem with many dietary supplements. Journal of Functional Foods 18 (2015) 994–1001
Good Fat In — Excess Fat Out
Clearly “fat” is not only obvious in describing obesity but is also, paradoxically, a key to ﬁnding a cure for obesity and co-morbid conditions. Addressing body fat with a “fat solution” rather than addressing risk factors alone has been postulated as a uniquely viable approach to potentially solving the epidemic of obesity.
The emerging target in dietary intervention to normalize body fat is the endocannabinoid system (ECS). The endocannabinoid system in the human body operates via one of the oldest structures in the brain, the limbic system, which regulates most basic functions commanding one's daily life.The ECSregulates metabolic functions, satiety and energy homeostasis and also regulates mood, memory and pain sensation; it owes its name to Cannabis indicis, since it mediates the psychoactive eﬀects of cannabis.
A high-fat diet stimulates the ECS, which results in accelerated building of body fat --this creates a truly vicious circle.Therefore, normalizing the overactive ECS, preventing excess fat intake and body fat build-up may prevent metabolic deterioration and obesity. Arguably, the stimulation of the ECS starts with excess dietary fatty acids that gradually incapacitate hepatocytes (liver cells), and compromise one of the major functions of the liver which is oxidation and utilization of fat for energy. A liver burdened with accumulated fat can be compared to a vacuum cleaner clogged with excess dirt. As a result nutritional fat is deposited throughout the body, leading to a characteristic central or abdominal obesity pattern.