Zembrin® is a standardized botanical extract targeted to combating effects of stress; it is derived from the several-thousand-year-old tradition of human use of the plant, Sceletium tortuosum (L.) N.E. Br. (Fam. Mesembryanthemaceae). The plant has been used daily by nomads inhabiting the western-southern portion of Africa. The tribal people living there, known as San, are considered to be the descendants of the earliest groups of modern humans. One of their most important food plants was the stamina-building Sceletium, which was chewed to prevent increasing stress and to impart mental and physical performance in the demanding lives of nomads who were hunters and gatherers. Only in the past 15 years Sceletium, in its standardized form as the brand Zembrin®, was systematically tested in-vitro, in-vivo and in clinical studies for its nutritional and functional properties that appears to be relevant to the ethnopharmacological uses.